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Autologous Ovarian Tissue Transplantation

NCT03496636 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2025-08-14

No results posted yet for this study

Summary

Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.

Conditions

  • Female Infertility

Interventions

PROCEDURE

Ovarian tissue transplant

Pieces of previously frozen ovarian cortex will be put in the abdomen laparoscopically, or with mini laparotomy

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Kyle Orwig, PhD · University of Pittsburgh/University of Pittsburgh Medical Center

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2026-09-01
Completion
2027-09-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03496636 on ClinicalTrials.gov