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The University of Pennsylvania Uterus Transplant for Uterine Factor Infertility Trial

NCT03307356 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2025-08-05

No results posted yet for this study

Summary

Options for childbearing are limited for the thousands of women in the United States who suffer from absolute uterine factor infertility. Uterine transplantation is an emerging treatment that provides hope for these individuals.

In the Penn UNTIL trial, the investigators plan to perform uterus transplants on five women who will ultimately undergo embryo transfer, pregnancy, delivery, and then transplant hysterectomy.

This trial is accepting women in need of a transplant and also women who are interested in being a live donor.

For more information please visit: https://clinicalresearch.itmat.upenn.edu/clinicaltrial/4821/congenital-abnormalitiesfemale-infertility-penn-ut/

Conditions

  • Mayer Rokitansky Kuster Hauser Syndrome
  • Uterine Agenesis
  • Infertility, Female, of Uterine Origin
  • Uterine Factor Infertility

Interventions

OTHER

Uterine Transplant

Transplant of a uterus from a donor, deceased or living

Sponsors & Collaborators

Principal Investigators

  • Kathleen E O'Neill, MD, MTR · University of Pennsylvania

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-10
Primary Completion
2029-07-01
Completion
2029-07-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03307356 on ClinicalTrials.gov