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Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study

NCT02622360 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2019-10-30

No results posted yet for this study

Summary

Developmental dyslexia is a highly heritable disorder in which reading skills are compromised despite normal intelligence and appropriate reading instruction. Reading problems in dyslexia are thought to primarily originate from weak speech sound representations or poor phonological skills. Dyslexia has also been associated with short-term or working memory dysfunctions. The current study will address the presence of these problems in dyslexic adults by the means of recording auditory and audio-visual mismatch negativity (MMN) and its magnetic counterpart (MMNm) to determine neural speech sound discrimination, representations and integration of seen and heard language. In addition to analyzing neural processing of syllables or (pseudo-)words, a new approach to MEG acquisition and analysis to characterize the neural responses during comprehension of complex real-life speech will be used. Furthermore, reading, phonological and cognitive skills of these participants will be determined with a neuropsychological test battery. The associations between the neural, neuropsychological and genetic measures will be studied. This project will illuminate the nature of neurocognitive dysfunctions in dyslexia and their relationship with genes.

Conditions

  • Dyslexia

Sponsors & Collaborators

  • Helsinki University Central Hospital

    collaborator OTHER

  • Karolinska Institutet

    collaborator OTHER

  • University of Helsinki

    lead OTHER

Principal Investigators

  • Teija Kujala, Prof. · Cognitive Brain Research Unit, Institute of Behavioural Sciences, University of Helsinki

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2017-04-30
Completion
2021-04-30

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02622360 on ClinicalTrials.gov