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Age-adjusted D-dimer Cut-off to Rule Out Pulmonary Embolism in the Emergency Department : A Real Life Impact Study

NCT02601846 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1507

Last updated 2021-05-06

No results posted yet for this study

Summary

A multicentre multinational prospective management outcome study has recently proven the safety of a diagnostic strategy combining clinical probability assessment with an age-adjusted D-dimer cut-off, defined as a value of (age x 10) in patients \> 50 years, for ruling out PE in outpatients, with a very low likelihood of subsequent symptomatic VTE. Moreover, this study showed that such a strategy increased the diagnostic yield of D-dimers, as it allowed ruling out PE without further investigation in a significantly higher proportion of patients than when using standard cut-off, particularly so in patients 75 years or older.

The objective of the present study is to confirm in a prospective cohort of "real life" patients the usefulness of the age-adjusted D-dimer cut-off to rule out PE in patients presenting to the emergency department with suspected PE.

Conditions

Interventions

OTHER

No intervention

This is an observational study, without any specific intervention.

Sponsors & Collaborators

  • University Hospital, Brest

    collaborator OTHER

  • European Georges Pompidou Hospital

    collaborator OTHER

  • University Hospital St Luc, Brussels

    collaborator OTHER

  • Centre Hospitalier Universitaire Vaudois

    collaborator OTHER

  • University Hospital, Angers

    collaborator OTHER_GOV

  • Centre Hospitalier d'Agen

    collaborator OTHER

  • University Hospital, Clermont-Ferrand

    collaborator OTHER

  • University Hospital, Geneva

    lead OTHER

Principal Investigators

  • Helia Robert-Ebadi, MD · Geneva University Hospitals and Faculty of Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-11-30
Primary Completion
2019-06-30
Completion
2019-06-30

Countries

  • Belgium
  • France
  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02601846 on ClinicalTrials.gov