MedTrace Logo

Acute Chest Pain Imaging in the ED With the Combine CCTA and CT Perfusion

NCT02538861 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2022-04-20

No results posted yet for this study

Summary

This is a prospective open label two arms clinical trial. ARM-A patients will receive the standard of care diagnostic test at Baptist Hospital Main (BHM), which includes Single Photon Emission Computed Tomography (SPECT) imaging, while ARM-B patients will be randomized sequentially into two groups; Group-1 will receive CT Angiography and CT myocardial perfusion with new Revolution CT scanner (General Electric Healthcare) while the Group-2 will receive SPECT imaging test; both groups of ARM-B at West Kendall Baptist Hospital (WKBH). The primary hypothesis is that the combined evaluation of CT angiography with CT myocardial perfusion is more efficient in detecting or excluding acute coronary syndrome resulting in early discharge and decrease length of stay of patients from the Emergency Department (ED) compared to a strategy with SPECT alone. The secondary hypothesis is that a strategy with CTA/CTP can reduce direct patient care costs and potentially improve patient outcomes in the same patient population when compared to a strategy with SPECT imaging alone.

The main purpose of this study is to have a definite ED chest pain admission triage, which will help to reduce the length of stay and direct patient cost. This approach will reduce the economic burden in intermediate risk group patients as well. We had a Baptist statistician run the numbers. This study will provide important preliminary data to guide clinical implementation of CTP/CTA in clinical practice. We divided arm B into two groups as the CT protocol might be different at each hospital, so we want to reduce bias as a result of variation in clinical patterns in the different hospitals. Also, we kept 50 patients in arm A (Baptist hospital) to have a control group at the hospital level.

Conditions

Interventions

DIAGNOSTIC_TEST

SPECT Imaging Test at Baptist hospital

Single Photon Emission Tomography (SPECT) testing at Baptist Hospital.

DIAGNOSTIC_TEST

CT Angiography and CT myocardial perfusion at West Kendall Baptist Hospital

The combined approach of CT Angiography and CT myocardial perfusion with new Revolution CT scanner

DIAGNOSTIC_TEST

SPECT Imaging Test at West Kendall Baptist Hospital

Single Photon Emission Tomography (SPECT) testing at West Kendall Baptist hospital.

Sponsors & Collaborators

  • GE Healthcare

    collaborator INDUSTRY

  • Baptist Health South Florida

    lead OTHER

Principal Investigators

  • Ricardo C Cury, MD · Baptist Health South Florida

Eligibility

Min Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2019-06-06
Completion
2019-06-06

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02538861 on ClinicalTrials.gov