Multicenter Study to Rule Out Myocardial Infarction by Cardiac Computed Tomography

Summary

The growing availability of cardiac computed tomography (CT)\* in emergency departments (EDs) across the U.S. expands the opportunities for its clinical application, but also heightens the need to define its appropriate use in the evaluation of patients with acute chest pain. To address this need, we performed a randomized diagnostic trial (RDT) to determine whether integrating cardiac CT, along with the information it provides on coronary artery disease (CAD) and left ventricular (LV) function, can improve the efficiency of the management of these patients (i.e. shorten length of hospital stay, increase direct discharge rates from the ED, decreasing healthcare costs and improving cost effectiveness while being safe).

Conditions

• Acute Coronary Syndrome
• Myocardial Infarction
• Unstable Angina Pectoris

Interventions

RADIATION

Cardiac Computed Tomography

A contrast enhanced cardiac CT was performed in addition to standard evaluation. Reconstructed data sets were evaluated for the presence of coronary artery calcium, coronary atherosclerotic plaque and stenosis, LV function and incidental findings.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Kaiser Permanente

  collaborator OTHER

• Beth Israel Deaconess Medical Center

  collaborator OTHER

• Bay State Clinical Trials, Inc.

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• Tufts Medical Center

  collaborator OTHER

• The Cleveland Clinic

  collaborator OTHER

• Northwestern University

  collaborator OTHER

• University of Maryland

  collaborator OTHER

• Massachusetts General Hospital

  lead OTHER

Principal Investigators

• Udo Hoffmann, MD, MPH · Massachusetts General Hospital

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-04-30

Primary Completion

2012-01-31

Completion

2012-03-31

Countries

• United States

Study Locations