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Dual-Source Computed Tomography to Improve Prediction of Response to Cardiac Resynchronization Therapy

NCT01097733 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2022-10-03

No results posted yet for this study

Summary

Cardiac Resynchronization Therapy (CRT) is a widely accepted treatment that has led to improved clinical outcomes for patients with refractory congestive heart failure (CHF), systolic dysfunction, and wide QRS duration. However, it requires implantation of an expensive device ($30,000) and about 1/3 of patients do not have clinical improvement. Inadequate amounts of LV dyssynchrony or suboptimal lead placement may limit clinical response. Dual-Source computed tomography (DSCT) allows for subtle detection during myocardial contraction for assessing LV dyssynchrony, and can also assess coronary venous anatomy and scar burden. Thus DSCT may be the ideal noninvasive modality to predict response to CRT.

Conditions

  • Heart Failure - NYHA II - IV
  • Wide QRS Complex

Interventions

OTHER

Randomization of Pre-knowledge of CT coronary venography

Sponsors & Collaborators

  • Brigham and Women's Hospital

    collaborator OTHER

  • Abbott Medical Devices

    collaborator INDUSTRY

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Jagmeet P Singh, MD, PhD · Massachusetts General Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2012-01-31
Completion
2012-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01097733 on ClinicalTrials.gov