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Effects of PEEP on Heart and Lungs in Obese Subjects

NCT02523352 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2020-11-17

No results posted yet for this study

Summary

Aim of this study is to better understand pathophysiology of the alteration of respiratory mechanics and cardiovascular function in obese volunteer subjects. The investigators plan to test this hypothesis with a physiological, interventional study conducted on volunteers by using Electrical Impedance Tomography in a group of patients and magnetic resonance imaging (MRI) in another group.

Conditions

  • Obesity
  • Pulmonary Atelectasis
  • Obesity Hypoventilation Syndrome
  • Magnetic Resonance Imaging
  • Respiratory Mechanics
  • Electrical Impedance Tomography
  • Trans-Thoracic Echocardiography

Interventions

PROCEDURE

Non-Invasive Ventilation

Progressive increase in airway pressure to open lungs atelectatic regions.

PROCEDURE

Esophageal catheter positioning

The esophageal tube (8 French diameter catheter) will be positioned in the larger nostril previous topical anesthesia

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Robert Kacmarek, RRT, PhD · Massachussets General Hospital

  • Lorenzo Berra, MD · Massachusetts General Hospital

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-05
Primary Completion
2021-12-31
Completion
2022-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02523352 on ClinicalTrials.gov