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Effect PEEP on Diaphragm

NCT03539640 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2020-05-20

No results posted yet for this study

Summary

This study evaluates the effect of positive end-expiratory pressure on the position, length and function of the diaphragm. During the first part of the study, physiological measurements of the diaphragm will be performed while participants receive non-invasive ventilation at different PEEP levels. During the second part of the study, MRI measurements of the diaphragm will be performed during a change in PEEP level.

Conditions

  • Diaphragm Disease

Interventions

OTHER

PEEP: 5 cmH2O

During second part of the study (MRI)

OTHER

PEEP: 10 cmH2O

During second part of the study (MRI)

OTHER

PEEP: 15 cmH2O

During second part of the study (MRI)

Sponsors & Collaborators

  • Amsterdam UMC, location VUmc

    lead OTHER

Principal Investigators

  • Leo Heunks, MD, PhD · Amsterdam UMC, location VUmc

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-13
Primary Completion
2018-12-12
Completion
2019-05-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03539640 on ClinicalTrials.gov