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Involvement of the Translation Initiation Factors in Resolution of Inflammation in the Elderly Population

NCT02519361 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2015-08-10

No results posted yet for this study

Summary

Aging cause specific changes in the immune system. Processes like "immunoessence" and "inflammaging" offend the functioning of the immune cells and expose the elderly patient to infections that can lead to morbidity and death.

Protein translation regulation offers a strategic advantage to the immune cells, because it enables rapid activation or termination of synthesis of specific proteins, required for inflammation or its resolution. Translation initiation depends on recruitment of eukaryotic initiation factor "eIF4F" complex.

The aim of the current study is to investigate the involvement of the translation initiation factors (eIF4E and eIF4G) in the process of recovery from acute infection in elderly patient admitted to the internal department with an acute infection.

Conditions

  • Infection in the Elderly

Sponsors & Collaborators

  • Meir Medical Center

    lead OTHER

Principal Investigators

  • Rachel Heffez Ayzenfeld, MD · r.h.ayzenfeld

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2016-01-31
Completion
2016-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02519361 on ClinicalTrials.gov