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Exercise on microRNA in Rheumatoid Arthritis

NCT05914337 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2023-06-22

No results posted yet for this study

Summary

The goal of this prospective cohort study is to learn about whether exercise alters microRNA expression levels in 30 rheumatoid arthritis patients and 30 healthy controls.

The main questions it aims to answer are:

* Does exercise affect microRNA expression levels related to the pathophysiology of rheumatoid arthritis?
* Are microRNA levels correlated with disease activity? Participants was applied program consisting of strengthening and stretching exercises 2 days a week for 8 weeks. One day a week, 30 minutes of mild moderate walking was requested.

Researchers will compare rheumatoid arthritis patients and healthy controls to see if that the microRNA expression levels of patients with rheumatoid arthritis as a result of exercise training would not make a significant difference with healthy controls.

Conditions

Interventions

BEHAVIORAL

exercise

A program consisting of strengthening and stretching exercises 2 days a week was applied to the study group for 8 weeks. One day a week, 30 minutes of mild moderate walking was requested.

BIOLOGICAL

gene expressions of miRNA

In the samples taken, gene expressions of miRNA-146a, miRNA-155, miRNA-16, miRNA-145 were determined by real-time polymerase chain reaction method.

Sponsors & Collaborators

  • Saglik Bilimleri Universitesi

    lead OTHER

Principal Investigators

  • Zeynep Betül ÖZCAN, M. Sc. · Saglik Bilimleri Universitesi

  • Fulya Senem KARAAHMETOĞLU, M. Sc. · Saglik Bilimleri Universitesi

  • Bekir ERDOĞAN, M. Sc. · Saglik Bilimleri Universitesi

  • Sibel KURAŞ, M. Sc. · Saglik Bilimleri Universitesi

  • Mehmet Zahid ÇIRACI, MD · Sakarya Training and Research Hospital

  • Halime Hanım PENÇE, Assoc. Pr · Saglik Bilimleri Universitesi

  • Meltem VURAL, Prof. Dr. · Istanbul Bakırköy Dr.Sadi Konuk Training and Research Hospital

  • Alev KURAL, Assoc. Pr. · Istanbul Bakırköy Dr.Sadi Konuk Training and Research Hospital

  • Işıl ÜSTÜN, MD · Istanbul Bakırköy Dr.Sadi Konuk Training and Research Hospital

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-01
Primary Completion
2019-09-11
Completion
2020-06-17

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05914337 on ClinicalTrials.gov