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Involvement of Translation Initiation Factors in the Immune Response in the Elderly

NCT01215604 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2012-03-19

No results posted yet for this study

Summary

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.

In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs\<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).

Conditions

Sponsors & Collaborators

  • Meir Medical Center

    lead OTHER

Principal Investigators

  • Rachel Heffez Ayzenfeld, MD · Meir Medical Center

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2011-10-31
Completion
2012-10-31

Countries

  • Israel

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01215604 on ClinicalTrials.gov