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Prediction of Erosive Disease in Early Rheumatoid Arthritis (RA) by Ultrasound and Cartilage Biodegradation Markers

NCT02464384 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2015-12-03

No results posted yet for this study

Summary

Multicenter, prospective, open-label, cohort study. Primary objective: Determination of the predictive value of US alone and in combination with cartilage biodegradation markers on radiographic progression (change in Ratingen score)

Secondary objectives:

* Correlation of ultrasound synovitis score and clinical disease activity score
* Determination of the sensitivity of ultrasound erosion detection compared to MRI
* Assessment of the value of including tenosynovitis assessment for predicting radiographic progression
* Assessment of the predictive value of ultrasound synovitis score at baseline for the need to install biologic DMARDs

Conditions

  • Erosive Disease in Early Rheumatoid Arthritis

Interventions

PROCEDURE

Venipuncture, ultrasound, MRI, x-ray

Collection of blood samples and ultrasound / MRI and x-ray examination

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Adrian Ciurea, MD · Department of Rheumatology, University Hospital Zurich

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2019-04-30
Completion
2019-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02464384 on ClinicalTrials.gov