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MSUS Versus Serum Survivin and Lubricin Levels in Evaluation of Disease Activity in JIA

NCT05545098 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 106

Last updated 2022-09-19

No results posted yet for this study

Summary

Aim of the work The aim of this study is to compare the role of musculoskeletal ultrasound to serum Survivin and Lubricin in detection of disease activity in patients with oligoarticular and polyarticular juvenile idiopathic arthritis.

Objectives

* To assess disease activity using Juvenile arthritis disease activity score in 27 joints (JADAS 27) in the studied JIA patients.
* To identify the prevalence of functional disability in JIA children and adolescents using the childhood health assessment questionnaire (CHAQ).
* To perform MSUS on the involved joints.
* To assess Survivin in the serum and in the synovial fluid if available in JIA patients.
* To assess Lubricin in the serum and in the synovial fluid if available in JIA patients.
* To compare the disease activity across individual patients using JADAS 27, MSUS and their relation to serum level of Survivin and lubricin.

Conditions

  • Juvenile Idiopathic Arthritis

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Mohamed G Mohamed, Ass prof · Assiut University

  • Manal M Ahmed, Ass prof · Assiut University

  • Nagwa A Mohamed, Prof · Assiut University

Eligibility

Min Age
2 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-30
Primary Completion
2024-05-31
Completion
2024-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05545098 on ClinicalTrials.gov