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Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock

NCT01149278 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 800

Last updated 2012-11-05

No results posted yet for this study

Summary

The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak. Indead there are only few prospective studies which addressed this question without clear answer. Therefore we designed a RCT in order to assess the effect on mortality of two levels of mean arterial pressure in patients with septic shock.(800 patients, 30 centres)

Conditions

  • Septic Shock
  • Arterial Pressure
  • Hemodynamics
  • Mortality
  • Clinical Trial

Interventions

DRUG

maintain mean arterial pressure between 80-85 mm Hg

protocolized hemodynamic care aiming to maintain mean arterial pressure between 80-85 mm Hg

OTHER

maintain mean arterial pressure between 65-70 mm Hg

protocolized hemodynamic care aiming to maintain mean arterial pressure between 65-70 mm Hg

Sponsors & Collaborators

  • University Hospital, Angers

    lead OTHER_GOV

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2012-09-30
Completion
2012-09-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01149278 on ClinicalTrials.gov