MedTrace Logo

Corticospinal Function After Spinal Cord Injury

NCT02451683 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-03-03

No results posted yet for this study

Summary

The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal cord injury (SCI). The investigator proposes to use modern electrophysiological methods to enhance the efficacy of residual corticospinal connections. Defining the neural basis by which corticospinal volleys generate muscle responses will provide crucial information required to maximize residual motor output. The investigator's specific goals are to: 1) determine the temporal and spatial organization of corticospinal volleys and motor cortical representations of upper-limb muscles after incomplete cervical SCI and 2) develop methodologies to promote recovery of function. The investigator's focus on reach and grasp movements because of their importance in daily life activities.

Conditions

  • Spinal Cord Injury

Interventions

OTHER

Electrophysiology Assessment of Time Domain

Kinematics, Spinal Cord Excitability and Cortical Spinal Motor Excitability.

OTHER

Electrophysiology Assessment of Location

Kinematics, Spinal Cord Excitability and Cortical Spinal Motor Excitability

OTHER

Training with some stimulation

motor task combined with real or sham stimulation

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • Shirley Ryan AbilityLab

    lead OTHER

Principal Investigators

  • Monica Perez, PT PhD · Shirley Ryan AbilityLab

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-12
Primary Completion
2025-12-31
Completion
2026-01-30

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02451683 on ClinicalTrials.gov