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Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI

NCT01272349 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2013-11-21

No results posted yet for this study

Summary

The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury. This idea stems from animal studies on respiration, in which investigators have shown that mild intermittent hypoxia improves breathing in spinally injured rats. These studies have shown that intermittent hypoxia induces spinal plasticity, strengthening neural connections and motor neuron function within the spinal cord. Exposure to mild intermittent hypoxia triggers a cascade of events, including increased production of key proteins and increased sensitivity of spinal cord circuitry necessary for improved breathing.

The ultimate goal of this research is to assess the potential of mild intermittent hypoxia as a therapeutic approach to stimulate recovery of limb function in human patients.

Conditions

  • Spinal Cord Injury

Interventions

OTHER

Acute intermittent hypoxia

30 minutes of intermittent breathing low oxygen followed by walking on a body-weight support treadmill

OTHER

Room air

30 minutes of breathing room air followed by walking on a body-weight support treadmill

Sponsors & Collaborators

  • Shirley Ryan AbilityLab

    collaborator OTHER

  • Shepherd Center, Atlanta GA

    collaborator OTHER

  • Northwestern University

    collaborator OTHER

  • University of Wisconsin, Madison

    collaborator OTHER

  • University of Saskatchewan

    collaborator OTHER

  • Emory University

    lead OTHER

Principal Investigators

  • Randy D Trumbower, PT, PhD · Emory University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-12-31
Primary Completion
2013-11-30
Completion
2013-11-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01272349 on ClinicalTrials.gov