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Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury

NCT01538693 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2015-05-19

No results posted yet for this study

Summary

The purpose of this study is to determine whether exercising (walking) at different intensities increases levels of factors in the blood and saliva that are known to impact neuroplasticity (how the connections in the spinal cord and brain can change) and if these levels are changed by pairing exercise with a single dose of commonly used prescription drugs or by your mood.

Conditions

  • Spinal Cord Injury

Interventions

DRUG

escitalopram oxalate

10 mg 4.5 hours prior to testing

DRUG

Cyproheptadine

8mg 4.5 hours prior to testing

DRUG

sugar pill

4.5 hour prior to testing

OTHER

Graded intensity exercise

modified bruce protocol for peak oxygen consumption testing

Sponsors & Collaborators

  • University of Medicine and Dentistry of New Jersey

    collaborator OTHER

  • Shirley Ryan AbilityLab

    collaborator OTHER

  • T. George Hornby

    lead OTHER

Principal Investigators

  • Thomas G Hornby, PhD, PT · University of Illinois at Chicago, Rehabiliation Institute of Chicago, Northwestern University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-12-31
Primary Completion
2015-05-31
Completion
2015-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01538693 on ClinicalTrials.gov