Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders

Summary

In this study the investigators will seek to improve our understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of mood, substance use, and eating behavior. The investigators will recruit 1000 individuals and use a wide range of assessment tools, neuroimaging measures, blood and microbiome collections and behavioral tasks to complete the baseline and follow-up study visits. Upon completion, the investigators aim to have robust and reliable dimensional measures that quantify these systems and a set of assessments that should be recommended as a clinical tool to enhance outcome prediction for the clinician and assist in determining who will likely benefit from what type of intervention.

Conditions

• Depression
• Anxiety
• Eating Disorders
• Drug Use Disorders

Interventions

BEHAVIORAL

standardized diagnostic assessment

BEHAVIORAL

self-report questionnaires

BEHAVIORAL

behavioral tasks

OTHER

physiological measurements

OTHER

structural and functional magnetic resonance imaging and EEG

OTHER

biomarker and microbiome assessments

OTHER

blood to derive induced pluripotent stem cells

OTHER

genetic and epigenetic assessments

Sponsors & Collaborators

• University of Oklahoma

  collaborator OTHER

• Rutgers University

  collaborator OTHER

• University of California, San Diego

  collaborator OTHER

• Laureate Institute for Brain Research, Inc.

  lead OTHER

Principal Investigators

• Martin P Paulus, M.D. · Laureate Institute for Brain Research

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2020-06-30

Completion

2020-06-30

Countries

• United States

Study Locations