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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

NCT02447692 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 575

Last updated 2025-05-22

No results posted yet for this study

Summary

For adult patients with acute respiratory failure requiring invasive mechanical ventilation, does a ventilation strategy using proportional assist ventilation with load-adjustable gain factors (PAV+) result in a shorter duration of time spent on mechanical ventilation than a ventilation strategy using pressure support ventilation (PSV)?

Conditions

  • Critically Ill
  • Acute Respiratory Failure

Interventions

OTHER

PSV ventilation strategy

An algorithm for adjusting the level of pressure support according to usual clinical parameters; patients not tolerating PSV will be switched to Assist/Control mode according to predefined criteria

OTHER

PAV+ ventilation strategy

An algorithm for adjusting the level of support (gain) to maintain a predefined range of respiratory muscle pressure; patients not tolerating PAV+ (Puritan Bennett™ 840 or 980 ventilator) will be switched to Assist/Control mode according to predefined criteria

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Medtronic

    collaborator INDUSTRY

  • Canadian Critical Care Trials Group

    collaborator OTHER

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Principal Investigators

  • Karen J Bosma · London Health Sciences Centre, London, Ontario, Canada

  • Laurent Brochard · St. Michael's Hospital, Toronto, Ontario, Canada

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-09-14
Primary Completion
2024-07-16
Completion
2024-07-16

Countries

  • Argentina
  • Canada
  • France
  • Greece
  • Italy
  • Saudi Arabia
  • Spain

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02447692 on ClinicalTrials.gov