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Effect of Bariatric Surgery on Gut Hormones Production and Cure of Type 2 Diabetes Mellitus

NCT01251016 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2015-12-08

No results posted yet for this study

Summary

Type 2 diabetes mellitus (T2DM) is a relevant public health problem and obesity has been associated as the major risk factor. Roux-en-Y gastric bypass is an effective method to treat severe obesity, and its metabolic benefits can lead to early and complete remission of T2DM, even before a considerable weight loss. We have hypothesized that intestinal anatomic changes may change intestinal genes expression related to glycemic control. The knowledge of mechanisms mediating the glycemic control after Roux-en-Y gastric bypass and it site of action in bowel may eventually help to develop alternative, less invasive and safer surgery for the treatment of T2DM, as well as drug development for the newly targets identified.

Conditions

  • Surgery

Sponsors & Collaborators

  • Pennington Biomedical Research Center

    collaborator OTHER

  • Federal University of São Paulo

    collaborator OTHER

  • University of Sao Paulo

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2015-12-31
Completion
2016-07-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01251016 on ClinicalTrials.gov