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Influence of Patient/Ventilador Decoupling in Neurocognitive and Psychopathological Sequelae in ICU Patients

NCT02390024 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 156

Last updated 2020-03-12

No results posted yet for this study

Summary

Mechanical ventilation (MV) is a vital support tool for critically ill patients. However, it may present several adverse effects, such as the development of cognitive and psychopathological alterations. Patient-ventilator asynchronies occur frequently since the beginning of the MV. These asynchronies are associated with poor clinical outcome and could be responsible for the neuronal changes causing these alterations. The objective of this project is to analyze the influence of patient-ventilation asynchronies in the development of long-term cognitive/psychopathological impairments and to explore the molecular mechanisms that could explain of these alterations. An exploratory, observational, multicenter, non-interventionist study will be performed in 150 ICU patients. The continuous recording of asynchronies and other clinical variables during ICU stay and the results of neuropsychological assessments will enable to identify clinical clusters associated with cognitive/psychopathological impairments.

Conditions

  • Critical Illness

Interventions

DEVICE

Invasive Mechanical Ventilation

Mechanical ventilation parameters will be monitorized during the ICU stay in all patients Four types of ventilators will be used: Servo Dräger Evita XL Dräger Evita 4 Puritan Bennet 840

Sponsors & Collaborators

  • Althaia Xarxa Assistencial Universitària de Manresa

    collaborator OTHER

  • Hospital Mutua de Terrassa

    collaborator OTHER

  • Corporacion Parc Tauli

    lead OTHER

Principal Investigators

  • Lluís Blanch Torra, PhD · Fundació Parc Taulí

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2018-03-31
Completion
2018-09-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02390024 on ClinicalTrials.gov