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Prebiotics Change Microflora and Decrease LPS

NCT02287844 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2014-11-17

No results posted yet for this study

Summary

The purpose of the present study was to establish the prebiotic effect of a new xylo-oligosaccharides (XOS) and of an inulin-and-XOS mixture (INU-XOS) and to determine their effect on endotoxaemia (lipopolysaccharides (LPS)) and immune parameters. In this randomized, parallel, placebo-controlled, double-blind study, sixty healthy volunteers were randomly assigned to three groups, receiving either 5 g XOS, INU-XOS (3 g inulin +1 g XOS) or an equivalent weight of wheat maltodextrins (placebo) during 4 weeks.

Conditions

  • Prebiotics Effect

Interventions

OTHER

XOS

5 g of XOS everyday for 4 weeks.

OTHER

INU-XOS

1 g of XOS and 3 g of inulin everyday for 4 weeks.

OTHER

Placebo

6.64 g of maltodextrins everyday for 4 weeks.

Sponsors & Collaborators

  • Institut Polytechnique LaSalle Beauvais

    collaborator OTHER

  • Institut Pasteur de Lille

    lead OTHER

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2008-12-31
Completion
2008-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02287844 on ClinicalTrials.gov