Exercise Training and Fitness in Severe Obesity

Summary

Obesity is commonly associated with insulin resistance and hyperinsulinemia, which seem to be linked with an impaired ability to oxidize lipids, particularly in class III obese individuals \[Body Mass Index (BMI): \> 40 kg\*m-2\]. Exercise training is an effective strategy to improve insulin sensitivity and to reduce the risk of type 2 diabetes.

This study aimed to compare the effects of two different 2-wk-long training modalities \[continuous at the intensity eliciting the maximal fat oxidation (Fatmax) versus adapted high intensity interval training (HIIT)\] on aerobic and metabolic fitness of class II and III obese men. It was hypothesized that, because of the nature of HIIT in the stimulation of rapid changes, aerobic fitness, fat oxidation rates during exercise and insulin sensitivity would be improved to a greater extent when adapted HIIT compared to Fatmax training.

Conditions

• Obesity

Interventions

OTHER

Fatmax group

For the Fatmax group each session will consist of 40-50 min of continuous exercise with an intensity that corresponded to the individual Fatmax (moderate intensity)

OTHER

HIIT group

For HIIT group, each session will consist of 10x60-s cycling intervals interspersed with 60-s of recovery. The workloads will be selected to elicit a heart rate of \~90% maximal heart rate during the intervals with a pedal rate of 90-100 revolutions.min-1, whereas during recovery, the participants will be allowed to pedal against a resistance of 50 W

Sponsors & Collaborators

• University of Lausanne

  collaborator OTHER

• Istituto Auxologico Italiano

  lead OTHER

Principal Investigators

• Stefano Lanzi, MSc · University of Lausanne, Department of Physiology

• Alberto Salvadori, MD · Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

• Franco Codecasa, MD · Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

• Mauro Cornacchia, MD · Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

• Davide Malatesta, PhD · University of Lausanne, Institute of Sport Sciences

• Paolo Fanari, MD · Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

45 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-01-31

Primary Completion

2013-12-31

Completion

2014-01-31

Countries

• Italy

Study Locations