Exercise in Prevention of Metabolic Syndrome

Summary

The primary objective of the study is to compare in a real-world setting the efficacy of traditional training (today's guideline, vigorously or moderate exercise) and amount of aerobic interval training (1-AIT) in reduction of risk factors constituting metabolic syndrome.

The secondary objective is to compare the efficacy of traditional moderate training (today's guideline) and amount of aerobic interval training (1-AIT vs. 4-AIT) in improving aerobic capacity, cardiovascular function, skeletal muscle contractile function, skeletal muscle energy metabolism, left ventricle systolic and diastolic function at rest and right ventricular function.

The investigators hypothesized that aerobic interval training would reverse features of the metabolic syndrome more than traditional training.

Conditions

• Metabolic Syndrome

Interventions

BEHAVIORAL

1x4 aerobic interval training

endurance training as walking/running "uphill" 3 times/week for 16 weeks (2 supervised sessions (treadmill) and 1 at home each week) at 90% of Hfmax. Warm-up 10 min at 70% of maximal heart frequency (Hfmax), 5min cool-down.

BEHAVIORAL

4x4 aerobic interval training

endurance training as walking/running "uphill" 3 times/week for 16 weeks (2 supervised sessions (treadmill) and 1 at home each week) at 90% of Hfmax. Warm-up 10 min at 70% of maximal heart frequency (Hfmax), 3 min active pause between each interval, 5min cool-down.

BEHAVIORAL

traditional moderate training

moderate intensity treadmill training (50-70% of HRmax) for a minimum of 30min, 5 times a week for 16 weeks (2 supervised sessions and 3 or more home).

Sponsors & Collaborators

• Helse Stavanger HF

  collaborator OTHER_GOV

• Technical University of Munich

  collaborator OTHER

• The University of Queensland

  collaborator OTHER

• KJ Fisiosport

  collaborator UNKNOWN

• University of Sao Paulo

  collaborator OTHER

• Norwegian University of Science and Technology

  lead OTHER

Principal Investigators

• Ulrik Wisløff, PhD prof · Norwegian University of Science and Technology

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-01-31

Primary Completion

2019-12-15

Completion

2019-12-15

Countries

• Australia
• Brazil
• Ecuador
• Germany
• Norway

Study Locations