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Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women

NCT02233283 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2015-08-21

No results posted yet for this study

Summary

Undernutrition has a known and well recognized negative impact on reproductive hormones, and ultimately fertility. In contrast, much less is known regarding the potential effects of overnutrition on the same hormones. Epidemiological data suggest that overnutrition might have a deleterious impact as well on the fertile potential of affected women, but very little is known about the mechanisms implicated. Such knowledge may be of importance, given the increasing prevalence of overweight and obesity worldwide.

Conditions

  • Female Reproductive System Disorder

Interventions

OTHER

Clamp

Volunteers will be submitted to hyperinsulinemic, euglycemic clamp studies of 10 hours duration.

OTHER

Hypercaloric diet

Hypercaloric diet will be conducted during one month, and designed to provide 30% excess in calories compared to daily requirements. It will consist in a high fat, high carbohydrates diet.

OTHER

Basal

Keeping the volunteers in the fasting state overnight and for the entire duration of the experiment (10 hours)

OTHER

Isocaloric diet

Isocaloric diet will conducted for one month, and designed to provide the calculated daily energy needs

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Francois P Pralong, MD · Centre Hospitalier Universitaire Vaudois

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2014-12-31
Completion
2015-06-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02233283 on ClinicalTrials.gov