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Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression

NCT03849417 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 128

Last updated 2024-06-25

No results posted yet for this study

Summary

This study investigates the relationships and differences in PET-MRI brain imaging biomarkers of abnormal aging and behavioral measures in late life depression compared to healthy controls, and evaluates relationships and differences in the same imaging and behavioral measures following electroconvulsive therapy. The study tests the hypotheses that late-life depression will be associated with higher levels of accelerated aging and brain disease biomarkers, and that electroconvulsive therapy works by stimulating the reorganization of brain tissue.The data collected with contribute to improved knowledge about the neurobiology of late-life psychopathology and its treatment.

Conditions

Interventions

OTHER

ECT

ECT administered as part of normal clinical management

Sponsors & Collaborators

  • KU Leuven

    collaborator OTHER

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Mathieu Vandenbulcke, MD, PhD · UZ Leuven / UPC-KU Leuven

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-06-19
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03849417 on ClinicalTrials.gov