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Respiratory Event-Related Potentials in Patients With Spinal Cord Injury

NCT02163551 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2017-10-30

No results posted yet for this study

Summary

Dyspnea is "a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity". It is known that sensory information from the respiratory system activates regions of the cerebral cortex to produce the perception of dyspnea but far less is known about the neurophysiology of dyspnea than about vision, hearing, or even pain. Dyspnea likely arises from multiple nervous system sources, but the exact locations have not been well identified. Investigations of the mechanisms underlying respiratory sensations have included studies of airway anesthesia, chest wall strapping, exercise, heart-lung transplantation, hyperventilation, and opioid use. Study of the perception of breathing sensations in individuals with a spinal cord injury presents additional opportunity. The goal of the proposed project is to examine the effects of increasingly severe levels of spinal cord injury on the perception of breathing sensations in participants who are able to breathe without the use of a ventilator. The investigators hypothesize that the perception of breathing varies with the extent of somatosensory information that reaches cerebral cortex.

Conditions

  • Spinal Cord Injury

Sponsors & Collaborators

  • Wake Forest University Health Sciences

    collaborator OTHER

  • University of North Carolina, Charlotte

    lead OTHER

Principal Investigators

  • Andrew Harver, PhD · University of North Carolina, Charlotte

  • Jesse A. Lieberman, MD, MSPH · Wake Forest University Health Sciences

Eligibility

Min Age
30 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2016-11-30
Completion
2016-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02163551 on ClinicalTrials.gov