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Mechanisms of Orthostatic Intolerance in Spinal Cord Injured Individuals and Following Bed Rest

NCT00175773 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 51

Last updated 2019-10-01

No results posted yet for this study

Summary

The primary purpose of this study is to investigate the relationship between the extent of neurologic (nerve) impairment in patients with spinal cord injuries and how well the nerves passing down the spine to the heart and blood vessels are working. These nerves are called the descending spinal sympathetic pathway (DSSP) and are important in controlling many functions, including blood pressure. We also wish to examine how injury severity and DSSP function influence blood levels of nor-epinephrine and epinephrine. Nor-epinephrine and epinephrine are hormones released into the blood that are also important in controlling blood pressure. Thus, we will also look at how the effect of the extent of DSSP dysfunction influences heart rate and blood pressure and blood levels of certain enzymes.

Conditions

  • Spinal Cord Injury

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Andrei Krassioukov, MD · University of British Columbia

Eligibility

Min Age
19 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-11-30
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00175773 on ClinicalTrials.gov