China Salt Substitute and Stroke Study

Summary

The study is a large scale cluster randomised trial to evaluate the effects of sodium reduction based upon the use of salt substitute on the risk of stroke defined as the occurrence of stroke and stroke deaths. The corresponding null hypothesis that will be tested is that sodium reduction will have no effect upon stroke risk. The secondary objectives are to determine effects of sodium reduction on major vascular events and total mortality.

Conditions

• Stroke

Interventions

BEHAVIORAL

Dietary sodium reduction

Ongoing dietary advice and a supply of a reduced-sodium added-potassium salt substitute

Sponsors & Collaborators

• Peking University

  collaborator OTHER

• Northwestern University

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• China Medical University, China

  collaborator OTHER

• Changzhi Medical College

  collaborator OTHER

• Centers for Disease Control and Prevention, China

  collaborator OTHER_GOV

• Ningxia Medical University

  collaborator OTHER

• Xi'an Jiaotong University

  collaborator OTHER

• The George Institute

  lead OTHER

Principal Investigators

• Bruce C Neal, PhD · The George Institute for Global Health, Australia

• Yangfeng Wu, PhD · The George Institute for Global Health at Peking University Health Science Centre

• Darwin Labarthe, PhD · Northwestern University Feinberg School of Medicine

• Paul Elliott, PhD · School of Public Health, Imperial College London

• Lijing L Yan, PhD · The George Institute for Global Health at Peking University Health Science Centre

• Nicole Y Li, PhD · The George Institute for Global Health, Australia

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-07-09

Primary Completion

2020-09-04

Completion

2020-09-04

Countries

• China

Study Locations