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Ketamine Patient-Controlled Analgesia for Acute Pain

NCT02062879 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2017-09-21

Study results available
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Summary

This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have similar or improved objective pain scores. Patients receiving ketamine are also expected to have shorter duration of supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is further expected to be associated with decreased intensive care unit and hospital lengths of stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and lower report of chronic pain syndromes.

Conditions

  • Acute Pain
  • Multiple Trauma
  • Fractures

Interventions

DRUG

Ketamine

Ketamine administered as patient-controlled analgesia.

DRUG

Hydromorphone

Hydromorphone administered as patient-controlled analgesia.

Sponsors & Collaborators

  • University of Cincinnati

    lead OTHER

Principal Investigators

  • Sheila C Takieddine, Pharm.D. · UC Health

  • Eric W Mueller, Pharm.D. · UC Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02062879 on ClinicalTrials.gov