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Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

NCT01591382 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2017-03-22

Study results available
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Summary

Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will improve pain relief in this subset of patients.

Conditions

  • Postoperative Pain

Interventions

DRUG

Ketamine

Intravenous (IV) ketamine 0.2 mg/kg/hr for 24-48 hours postoperatively.

DRUG

Placebo

Patients who received ketamine-matching placebo were given saline infusions

DRUG

Hydromorphone PCA

Intravenous hydromorphone PCA

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Srdjan S Nedeljkovic, M.D. · Brigham and Women's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-09-30
Primary Completion
2011-06-30
Completion
2012-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01591382 on ClinicalTrials.gov