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Optimization of MRI for Radiation Therapy

NCT02045381 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2025-01-14

No results posted yet for this study

Summary

Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Conditions

  • Cancer Liver
  • Cancer Brain
  • Cancer Head &Neck
  • Cancer Pelvis

Interventions

PROCEDURE

MRI Group

A single research MRI

Sponsors & Collaborators

  • University of Michigan Rogel Cancer Center

    lead OTHER

Principal Investigators

  • Shruti Jolly, MD · University of Michigan

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-03-14
Primary Completion
2023-02-09
Completion
2023-02-09

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02045381 on ClinicalTrials.gov