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Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction

NCT02045004 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2018-11-23

No results posted yet for this study

Summary

Despite an ongoing controversy in the scientific literature, the link between anesthesia and dementia and/or cerebral atrophy remains unclear. Recent retrospective data suggests an association of surgery with a reduction in brain volume. With the present prospective cohort study, we would like to reproduce and verify these results, and investigate a possible association with the postoperative cognitive performance.

We will measure cerebral gray matter volumes in elderly patients before, 3 and 12 months after major non-cardiac surgery and determine cognitive functions at the same time.

Study hypothesis:

1. Surgery under general anesthesia in elderly patients is associated with a loss of gray matter.
2. The degree of cognitive dysfunction is associated with the loss of grey matter in brain areas relevant for cognitive functions.

Conditions

  • Postoperative Cognitive Dysfunction
  • Delirium
  • Dementia

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    collaborator OTHER

  • Nicolai Goettel

    lead OTHER

Principal Investigators

  • Nicolai Goettel, MD · Department of Anesthesia, University Hospital Basel, Switzerland

  • Luzius A Steiner, MD, PhD · Department of Anesthesia, University Hospital Basel, Switzerland

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-14
Primary Completion
2017-11-30
Completion
2018-11-30

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02045004 on ClinicalTrials.gov