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Postoperative Cognitive Dysfunction in Geriatric Patients

NCT00512200 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 280

Last updated 2015-10-16

No results posted yet for this study

Summary

Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.

Conditions

  • Delirium, Dementia, Amnestic, Cognitive Disorders
  • Postoperative Complications
  • Memory Disorders

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Luzius A Steiner, MD, Prof. · Department of Anaesthesia, University Hospital Basel

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-07-31
Primary Completion
2012-02-29
Completion
2012-02-29

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00512200 on ClinicalTrials.gov