Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis Criterion

Summary

This is a multicentric and prospective study for the validation of a diagnostic method in multiple sclerosis. Our hypothesis is that there is a characteristic profile of tears that can be recognized in order to help in the diagnosis of this pathology and that could possibly replace the lumbar punction which is an invasive method. Semi-automatic and automatic techniques of isoelectric focusing will be developed for analyzing data from tears. These results will help in the identification of markers of this disease.

Conditions

• Clinically Isolated Syndrome
• Multiple Sclerosis

Interventions

PROCEDURE

tears and cerebrospinal fluid sampling

All patients recruited in this study will undergo a cerebrospinal fluid sampling which is an invasive procedure included in the actual routine practice. In addition a sampling from eyes will be obtain using the Schirmer test to get tears from the lacrimal gland.

Sponsors & Collaborators

• Lille Catholic University

  lead OTHER

Principal Investigators

• Gérard Forzy, MD · Groupement des Hôpitaux de l'Institut Catholique de Lille

• Patrick Hautecoeur, MD · Groupement des Hôpitaux de l'Institut Catholique de Lille

• Patrick Vermersch, MD, PhD · Centre Hospitalier Régional, Universitaire de Lille

• Gilles Defer, MD · Centre Hospitalier Universitaire Caen

• Christine Lebrun-Fresnay, MD, PhD · Centre Hospitalier Universitaire de Nice

• Jérôme de Seze, MD, PhD · Centre Hospitalier Régional Universitaire de Strasbourg

• Thibault Moreau, MD · Centre Hospitalier Universitaire Dijon

• Pierre Clavelou, MD · University Hospital, Clermont-Ferrand

• Olivier Heinzlef, MD · Centre Hospitalier Intercommunal Poissy-St-Germain

• Christian Confavreux, MD · Centre Hospitalier Universitaire de Lyon

• Marc Debouverie, MD, PhD · Central Hospital, Nancy, France

• Jean Pelletier, MD, PhD · Hopital de la Timone, Marseille

• Bruno Brochet, MD, PhD · University Hospital, Bordeaux

• Sandrine Wiertlewski, MD · Nantes University Hospital

• Albert Verier, MD · Centre Hospitalier de Valenciennes

• Bertrand Bourre, MD · University Hospital, Rouen

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-10-31

Primary Completion

2018-06-30

Completion

2018-12-31

Countries

• France

Study Locations