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Evaluation of Nutritional Status and Fatigue in Patients With Multiple Sclerosis

NCT02008669 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 360

Last updated 2018-08-21

No results posted yet for this study

Summary

Multiple sclerosis (MS) is a chronic progressive neurological disease, the leading cause of disability after injury accidents in young adults. Among the many symptoms, fatigue is very common with a significant impact on quality of life. Also, the disability caused by multiple sclerosis can alter food intake and can cause nutritional deficiencies. Nutrients such as proteins, minerals (iron, calcium, magnesium), some vitamins (B12, 25 OHD) are often deficient in this population with consequences in physical performance such as endurance and muscle strength. We propose to study the link between fatigue and shortcomings encountered in a defined population of MS patients.

Conditions

Interventions

PROCEDURE

Blood sampling

A blood sample will be taken from each patient and the following parameters will be assessed : magnesium, albumin, Vitamin B12, Vitamin D, Calcium, Iron.

OTHER

Gustatory sensitivity test using Taste strips

16 Taste Strips impregnated with 4 flavors (sweet, sour, salty, bitter, each flavor present at 4 different concentrations), are offered to the patient one after the other in a so-called pseudorandomized sequence. The task of the patient is to choose one of the following answers: sweet / sour / salty / bitter / no taste. Each correct answer is granted one point. In addition to the impregnated strips, two tasteless strips can be integrated in the examination at any point of time (no point)

OTHER

Questionnaires

Evaluation of the following parameters by validated questionnaires (name of the questionnaire in bracket): * Fatigue (EMIF-SEP) * Dysphagia (DYMUS) * Food intake (semi-structured questionnaire) * Depression (BDI-II) * Daily energy expenditure (NAP) * Visual analog scale to study quality of sleep

Sponsors & Collaborators

  • Lille Catholic University

    lead OTHER

Principal Investigators

  • Cécile Donzé, MD · Groupement des Hôpitaux de l'Institut Catholique de Lille

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-11-30
Primary Completion
2017-06-09
Completion
2017-06-09

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02008669 on ClinicalTrials.gov