Tear Analysis in the Diagnosis of Multiple Sclerosis

Summary

In the primary progressive multiple sclerosis, the detection of oligoclonal bands in cerebrospinal fluid is critical for the diagnosis. However, lumbar puncture for cerebrospinal fluid collection is considered relatively invasive. Our hypothesis is that oligoclonal bands detection in tears is possible and useful for the diagnosis of multiple sclerosis.

Conditions

• Primary Progressive Multiple Sclerosis

Interventions

PROCEDURE

tears sampling

Sponsors & Collaborators

• Bayer

  collaborator INDUSTRY

• Lille Catholic University

  lead OTHER

Principal Investigators

• Patrick Hautecoeur, MD · Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL)

• Elisabeth Baumelou, MD · Groupement des Hôpitaux de l'Institut Catholique de Lille

• Patrick Vermersch, MD, PhD · Centre Hospitalier Régional, Universitaire de Lille

• Christine Lebrun-Frenay, MD, PhD · Centre Hospitalier Universitaire de Nice

• Jérome De Sèze, MD, PhD · Centre Hospitalier Régional Universitaire de Strasbourg

• Thibaut Moreau, MD · Centre Hospitalier Universitaire Dijon

• Pierre Clavelou, MD · Centre Hospitalier Régional Universitaire de Clermont-Ferrand

• Olivier Heinzlef, MD · Centre hospitalier intercommunal de Poissy

• Christian Confavreux, MD · Hospices Civils de Lyon

• Marc Debouverie, MD, PhD · Central Hospital, Nancy, France

• Jean Pelletier, MD, PhD · L'assistance Publique des Hôpitaux de Marseille

• Bruno Brochet, MD, PhD · University Hospital, Bordeaux

• Gilles Defer, MD · Centre Hospitalier Universitaire de Caen

• Eric Thouvenot, MD · Centre Hospitalier Universitaire de Nîmes

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-04-30

Primary Completion

2016-03-31

Completion

2016-03-31

Countries

• France

Study Locations