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Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

NCT05177523 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2024-12-16

No results posted yet for this study

Summary

This project is to:

1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients.
2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period.
3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Conditions

  • Multiple Sclerosis (MS)
  • Relapsing-remitting Multiple Sclerosis (RRMS)
  • Secondary-progressive Multiple Sclerosis (SPMS)
  • Primary Progressive Multiple Sclerosis (PPMS)

Interventions

DIAGNOSTIC_TEST

MRI

Each enrolled subject will undergo a MRI at baseline and a second MRI at 2 years (+/- 3 months) follow-up.

OTHER

Neurocognitive examination for healthy subjects

Neurocognitive examination for healthy subjects will be performed at both baseline and follow-up

OTHER

blood sampling

Each enrolled subject will undergo a blood sampling (10 ml) at baseline

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Cristina Granziera, Prof. Dr. med. · Department of Neurology, University Hospital Basel

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-04
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05177523 on ClinicalTrials.gov