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Breath Metabolomics of Placebo Effects, a Pilot Study

NCT04956718 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2022-03-15

No results posted yet for this study

Summary

This study is to analyze the breath metabolome before and after the administration of a placebo in an established experimental pain procedure in healthy subjects in order to investigate placebo effects, and whether they induce any measurable changes at the metabolic level.

Conditions

  • Analgesia

Interventions

OTHER

Cold Pressor Test (CPT)

Cold Pressor Test (CPT): apparatus for the task is a tank of water of temperature of 4 °C (+-0.5 °C), with instruction to immerse the hand until too uncomfortable to continue. A maximum time limit per immersion of 3-5 min is applied. Quantitative measurement can then be made of pain threshold (point first perceived as painful) and tolerance time.

OTHER

Placebo NaCl Nasal spray

placebo nasal spray containing NaCl solution

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • University Children's Hospital Basel

    lead OTHER

Principal Investigators

  • Pablo Sinues, Prof. Dr. · Universitäts-Kinderspital beider Basel (UKBB)

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-21
Primary Completion
2022-01-26
Completion
2022-01-26

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04956718 on ClinicalTrials.gov