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Baseline Cortical Haemodynamics in MS

NCT02481882 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2018-10-12

No results posted yet for this study

Summary

This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease. It will also instruct us as to the most effective scanning protocols for future research. Developing a suitable protocol for studying perfusion longitudinally may also enable identification of new therapeutic interventions to normalise any perfusion abnormalities in MS patients.

Conditions

Interventions

DEVICE

Magnetic Resonance Imaging

All scanning will be performed using a 7 Tesla Philips Achieva scanner with multi-transit capability (Philips Medical Systems, Best, The Netherlands). The volunteers will be scanned with a 32-channel receive coil.

DRUG

Prohance (Gadoteridol)

A gadolinium based liquid administered intravenously in order to quantify blood flow in the brain using an MR scanner.

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Nikos Evangelou, Ph.D. · Faculty of Medicine & Health Sciences

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-31
Primary Completion
2019-10-31
Completion
2019-10-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02481882 on ClinicalTrials.gov