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Cardiovascular Responses to Cold in Hypertension

NCT02007031 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 91

Last updated 2013-12-11

No results posted yet for this study

Summary

Wintertime is associated with increased morbidity and mortality and a majority is related to cardiovascular causes, such as myocardial infarctions, heart failures, and strokes. It is also known, that both acute and long-term cold exposure increase blood pressure and cardiac workload, and this may contribute to the observed excess morbidity and mortality during the cold season.

Although the effects of cold on blood pressure are known among healthy people, these responses among risk groups, such as hypertensive people, are not established. In addition, changes in cardiac electrical activity or autonomic regulation are largely unknown. The cardiovascular responses in the cold could be different among hypertensive people because of disturbances in the circulatory regulation or function, such as aortic stiffening and increased vasomotor tone of peripheral arteries due to endothelial dysfunction associated with the disease. To assess this, a controlled experiment employing a cold exposure similar to everyday winter circumstances in a subarctic climate was performed.

Conditions

Sponsors & Collaborators

  • Finnish Institute for Health and Welfare

    collaborator OTHER_GOV

  • Finnish Institute of Occupational Health

    collaborator OTHER

  • Verve Research, Oulu, Finland

    collaborator OTHER

  • University of Oulu

    lead OTHER

Principal Investigators

  • Tiina M Ikäheimo, Ph.D. · University of Oulu

  • Jouni JK Jaakkola, MD, Ph.D. · University of Oulu

Eligibility

Min Age
55 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2011-11-30
Completion
2011-11-30

Countries

  • Finland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02007031 on ClinicalTrials.gov