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Long-term Neurocognitive Sequelae of Subclinical Microembolization During Carotid Interventions

NCT01718600 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 207

Last updated 2022-08-29

No results posted yet for this study

Summary

Microembolization is commonly associated with carotid artery stenting (CAS), but our understanding of subclinical microembolization is superficial. Through collaborative effects of multidisciplinary team-experts, novel approaches, and longitudinal evaluations, we hope to better understand the clinical significance and long-term cognitive effects of microemboli. This proposal may change our current clinical practice by providing a better outcome measure for carotid interventions and improving outcomes of CAS procedures through risk factor stratification. Our central hypothesis is that development of subclinical microemboli is associated with decline in cognitive function following CAS and that the risk of development of microemboli themselves is associated with patient- and procedure-related factors. We hope that this prospective study will help to clarify these important issues in the era of rapidly evolving percutaneous interventions.

Conditions

  • Carotid Artery Stenosis

Interventions

BEHAVIORAL

Neuropsychological testing

Sponsors & Collaborators

  • University of Wisconsin, Madison

    collaborator OTHER

  • Washington University School of Medicine

    collaborator OTHER

  • Stanford University

    lead OTHER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-06-30
Primary Completion
2018-04-30
Completion
2018-04-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01718600 on ClinicalTrials.gov