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Genetic Etiology in Premature Ovarian Insufficiency

NCT01973075 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2017-08-11

No results posted yet for this study

Summary

Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (\<40 years of age).Today, only 35% of POI's etiology can be explained. Causes enlightening POI may be enumerated as follows, according to their frequency: genetic mutations, autoimmune defects and abnormalities detected on the X chromosome.The purpose of the study is to determine the frequency of the genetic abnormalities and polymorphisms described above in the POI Turkish population

Conditions

  • Primary Ovarian Insufficiency
  • Genetic Predisposition to Disease

Sponsors & Collaborators

  • Istanbul University

    collaborator OTHER

  • BEGUM AYDOGAN

    lead OTHER

Principal Investigators

  • Engin Oral, Prof,OBGYN · Istanbul University

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-11-30
Primary Completion
2016-04-30
Completion
2017-04-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01973075 on ClinicalTrials.gov