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Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

NCT00471731 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2018-02-14

No results posted yet for this study

Summary

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Conditions

  • Turner Syndrome
  • Ovarian Failure, Premature
  • Sex Chromosome Aberrations
  • Menopause
  • Perimenopause

Sponsors & Collaborators

  • National Eye Institute (NEI)

    lead NIH

Principal Investigators

  • Janine A Clayton, M.D. · National Eye Institute (NEI)

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-05-07
Completion
2014-11-13

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00471731 on ClinicalTrials.gov