Ovarian Reserve and Matrix Metalloproteinases

Summary

Primary Ovarian Insufficiency (POI) is dysfunction of ovaries before 40 years of age. It has been reported that genetic factors, endocrine disorders, previous pelvic surgeries, chemotherapy and radiotherapy, and autoimmune mechanisms play a role in 10%, however the etiology has not been clarified in 90% of the cases. Oxidative stress and autoimmunity has been shown to be responsible in the etiopathogenesis of POI. Prolidase is an imidodipeptidase. Prolidase was shown to be related with oxidative stress and autoimmune diseases in previous studies. In addition, it is thought that the level of prolidase plays a role both in the etiopathogenesis and progression of diseases. This study aims to investigate the level of prolidase enzyme in women with POI.

Conditions

• Oxidative Stress
• Ovarian Insufficiency, Primary
• Ovarian Failure, Premature

Interventions

DIAGNOSTIC_TEST

Prolidase Level

Measurement of venous blood serum level of prolidase enzyme level by ELISA method.

DIAGNOSTIC_TEST

Follicle Stimulating Hormone Level

Measurement of venous blood serum level of follicle stimulating hormone level.

DIAGNOSTIC_TEST

Estradiol Level

Measurement of venous blood serum level of estradiol hormone level.

DIAGNOSTIC_TEST

Proline Level

Measurement of venous blood serum level of proline level.

DIAGNOSTIC_TEST

Hydroxyproline Level

Measurement of venous blood serum level of hydroxyproline level.

DIAGNOSTIC_TEST

Anti-mullerian Hormone Level

Measurement of venous blood serum level of anti-mullerian hormone level.

DIAGNOSTIC_TEST

Antral Follicle Count

Ultrasonographic evaluation of antral follicle count to determine ovarian reserve.

DIAGNOSTIC_TEST

Prolactine Level

Measurement of venous blood serum prolactine hormone level.

DIAGNOSTIC_TEST

Thyroid Stimulating Hormone Level

Measurement of venous blood serum thyroid stimulating hormone level.

Sponsors & Collaborators

• Ankara City Hospital Bilkent

  lead OTHER

Principal Investigators

• Esin Merve Erol Koç, MD · Ankara City Hospital Bilkent

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-08-10

Primary Completion

2022-02-12

Completion

2022-03-07

Countries

• Turkey (Türkiye)

Study Locations