MedTrace Logo

Double-blind Trial of Mannitol Cream to Block the Effect of Capsaicin Cream

NCT01963910 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2014-03-04

No results posted yet for this study

Summary

Capsaicin is a TRPV1 (transient receptor potential vanilloid 1) agonist, causing pain upon application. The investigators wish to determine whether mannitol blocks the effect of capsaicin application. As both cream bases are identical and mannitol addition is the only difference between the creams, if the mannitol cream is more effective in blocking the effect of capsaicin on the TRPV1 (transient receptor potential vanilloid 1) receptor, the investigators will have established that mannitol down-regulates or blocks the TRPV1 (transient receptor potential vanilloid 1) receptor.

Conditions

Interventions

DRUG

30% Mannitol in vehicle cream

applied to one half of the upper lip following removal of capsaicin cream.

DRUG

vehicle cream

application to the other half of the upper lip following capsaicin cream removal

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Helene Bertrand, MD, CM, CCFP · Department of family practice, University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01963910 on ClinicalTrials.gov