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Transient Receptor Potential Channels

NCT06444594 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2025-01-17

No results posted yet for this study

Summary

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Conditions

  • Aging

Interventions

DRUG

TRPM8 Agonist

menthol gel 4-10%

DRUG

TRPV1 Agonist

camphor gel 5-20%

DRUG

TRPV4 Agonist

capsaicin gel 0.05-1%%

DRUG

TRPM8, TRPV4, TRPV1 Agonists

menthol (4-10%), capsaicin (0.05-1%), camphor (5-20%)

OTHER

Vehicle gel

Inactive vehicle gel

Sponsors & Collaborators

  • Penn State University

    lead OTHER

Principal Investigators

  • Lacy Alexander, Ph.D. · Penn State University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-17
Primary Completion
2025-12-31
Completion
2026-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06444594 on ClinicalTrials.gov