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Blackberry Flavonoid Absorption and Effects on Intestinal Bacteria

NCT01944579 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2014-07-22

No results posted yet for this study

Summary

Intestinal bacteria can metabolize unabsorbed polyphenols (plant compounds) to produce smaller molecules which may impact health. In addition, evidence suggests that this process may be affected by body fatness. This study aims to investigate absorption of blackberry polyphenols, their impact on intestinal bacteria, polyphenol metabolites formed by intestinal bacteria, and how these processes differ for obese and lean individuals. It is hypothesized that polyphenol absorption and metabolism will differ between obese and lean individuals and that differences in intestinal microbiota may play a role.

Conditions

  • Metabolic Syndrome

Interventions

OTHER

Blackberries

Participants will receive blackberries as part of a controlled diet.

OTHER

Control

Participants will receive a control food (jello) as part of a controlled diet.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Janet Novotny

    lead FED

Principal Investigators

  • Janet A Novotny, Ph.D. · USDA Beltsville Human Nutrition Research Center

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2014-04-30
Completion
2014-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01944579 on ClinicalTrials.gov