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Optimal Fluid Management in Adult Severe Malaria

NCT01936766 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 156

Last updated 2018-08-16

No results posted yet for this study

Summary

Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited. Recent studies suggest that liberal fluid resuscitation is harmful for severe malaria patients despite they often being hypovolemic on admission. In order to elucidate the minimum fluid therapy required to prevent complications in severe malaria, we will conduct a prospective observational study in adults with severe malaria, and also in adults with severe sepsis as a comparison group. The objective of this study is to describe the association between hemodynamic variations in conventional fluid management and the probability of developing acute kidney injury (AKI) or pulmonary edema in adults with severe malaria and severe sepsis. Hemodynamic measurements will be obtained by using transpulmonary thermodilution and arterial pulse contour analysis.

Conditions

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Principal Investigators

  • Arjen Dondorp, MD · Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University

Eligibility

Min Age
16 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • Bangladesh

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01936766 on ClinicalTrials.gov